Gynecomastia in multi-drug resistant tuberculosis — ethionamide the villain
نویسندگان
چکیده
منابع مشابه
Multi-drug resistant tuberculosis in Northern Pakistan.
OBJECTIVE To determine the resistance pattern of Mycobacterium tuberculosis isolates in Rawalpindi-Islamabad. METHODS The study was carried out at the Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi between September 2000 and August 2002. We examined 1359 pulmonary and extra-pulmonary specimens from suspected cases of tuberculosis. The radiometric Bactec 460 TB sys...
متن کاملEthionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis.
Ethionamide (ETA) is an important component of second-line therapy for the treatment of multidrug-resistant tuberculosis. Synthesis of radiolabeled ETA and an examination of drug metabolites formed by whole cells of Mycobacterium tuberculosis (MTb) have allowed us to demonstrate that ETA is activated by S-oxidation before interacting with its cellular target. ETA is metabolized by MTb to a 4-py...
متن کاملDetection of KatG/inhA Mutation to Guide Isoniazid and Ethionamide Use for Drug-resistant Tuberculosis
BACKGROUND Depending on the presence of mutations that determine isoniazid (INH) susceptibility (katG and inhA), Mycobacterium tuberculosis may be susceptible to high doses of INH or ethionamide (ETH). OBJECTIVE To describe the INH resistance profile and association of katG mutation with previous INH treatment and level of drug resistance based on rapid molecular drug susceptibility testing (...
متن کاملPattern of Adverse Effects of Drugs Used to Treat Multi Drug Resistant Tuberculosis
During treatment of multi drug resistant tuberculosis (MDR-TB), patients suffer from many adverse effects. Severe adverse effects may lead to refusal and discontinuation of treatment. Though national tuberculosis control programs are generally well structured, they do not collect information on adverse effects of drug directly. This study had been designed to observe the pattern of adverse effe...
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ژورنال
عنوان ژورنال: Advances in Respiratory Medicine
سال: 2020
ISSN: 2543-6031,2451-4934
DOI: 10.5603/arm.2020.0093